The McInerney Laboratory at Karolinska Institutet, Stockholm, Sweden
This page describes the research and teaching activities of Gerry McInerney's research group in the Department of Microbiology, Tumor and Cell Biology at the Karolinska Institutet.
July 2019 group picture.
Back row: Gerry McInerney, Marc Panas, Benjamin Götte, Leo Hanke, Eline van Huizen.
Front row: Lifeng Liu, Ainhoa Moliner Morro, Paula Lafqvist Boqvist, Timothy Tan, Amitis Djalali.
Happy New Year!
Ben's latest paper, 'Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing', has been published in the Journal of Virology.
We welcome to the group a new postdoctoiral researcher, Laura Perez Vidakovics. Very welcome!
We welcome to the group a new PhD student, Siwen Long. Very welcome!
Congratulations to Ben who successfully defended his PhD degree on 20th September. Very well done!
Gerry, Lifeng and Ben attended the Keystone conference on positive strand RNA viruses in Killarney, Ireland
Congratulations to Lifeng who successfully defended his PhD degree on 24th May. Very well done!
Ben's latest paper 'Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery' is now accepted for publication at PLoS Pathogens. Link soon.
Our new work, 'Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery' is now available at biorXiv
We are very happy to have received 2 large research grants this month:
4 years support (2019-2022) from the Swedish Research Council (Vetenskapsrådet) and 3 years (2019-2021) from the Swedish Cancer Society (Cancerfonden).
Gerry recorded an episode of the Radioscience podcast (Swedish).
We have moved to our awesome new space at the Biomedicum building at KI. Looking forward to many productive years ahead!
Two papers accepted for publication this month:
'Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib' by Ladds et al, published in PLoS ONE
'Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus' by Mutso, Moliner Morro et al, published in Viruses.
A review article 'The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last' by Ben, Lifeng and Gerry is now published in the Viruses special issue on Advances in Alphavirus Research.
Our latest paper on the mechanism of PI3K activation by alphaviruses in has been accepted for publication in PLoS Pathogens.
Gerry won the Dept Microbiology, Tumour and Cell Biology Pedagogical Award for 2017.
Congratulations to Leo, who has received a postdoctoral stipend from the David and Astrid Hagelén Foundation.
Congratulations to Ben, who passed his PhD half time control with flying colours on 1st December!
Some of Ben's microscopy images have been selected to appear in an art exhibition, The Invisible Body at Sven Harrys Art Museum in Stockholm. See an article on the KI website. And even this clip on Swedish morning TV.
Gerry is currently taking a 5 month sabbatical as a visiting professor at the Lee Kong Chian School of Medicine, Singapore.
Congratulations to Marc, who has received a postdoctoral stipend from the Swedish Society for Medical Research (Svenska Sällskapet för Medicinsk Forskning, SSMF)
Also, welcome to the group as a postdoctoral researcher, Dr Leo Hanke
We welcome Marc Panas back to the group as a postdoctoral researcher.
New paper accepted for publication in ChemMedChem: 'Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin' in collaboration with Torsten Steinmetzer (Philipps-Universität Marburg).
Cecilia Nordfors joins the group as a postdoctoral researcher.
New paper accepted for publication in the Journal of Virology: 'The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling' in collaboration with Tero Ahola (Helsinki), Lisa FP Ng (A*Star Singapore) and others.
Our latest paper 'Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication' has just been accepted for publication in Open Biology.
Sayoni Chakraborty from the KI Biomedicine program has joined the group for a summer internship.
Two papers accepted for publication this week:
'Effects of an in-frame deletion of the 6k gene locus from the genome of Ross River virus', in collaboration with Suresh Mahalingam (Griffith University) in Journal of Virology.
'G3BP/Caprin1/USP10 complexes mediate SG condensation and associate with 40S ribosomal subunits' in collaboration with Nancy Kedersha and Paul Anderson (Harvard Medical School and Brigham and Women's Hospital) in Journal of Cell Biology.
Gerry has been accepted for the STINT Teaching Sabbatical program and will spend August to December 2016 teaching at Nanyang Technological University, Singapore. UPDATE: Gerry's sabbatical has been postponed until August to December 2017.
An interview with Gerry about the Karolinska Institutet Summer Research School was published in Kemivärlden Biotech (Swedish).
Bastian's paper 'Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation' has been accepted for publication in the Journal of Virology.
Bastian has been awarded the prestigious Jonas Söderquist Prize for Basic Research in Immunology and Virology 2015. Very well deserved!
Gerry hosted a one day symposium at Nobel Forum, Karolinska Institutet to celebrate the 30th anniversary of the Summer Research School for High School Students (Sommarforskarskolan för Gymnasieelever).
Gerry's short article on 'FGDF Motif Regulation of Stress Granule Formation' has been accepted for publication in DNA and Cell Biology.
A review article, 'Methods for the characterization of stress granules in virus-infected cells', by Panas, Kedersha and McInerney has been accepted for publication in Methods.
Gerry gave a talk at the Society for General Microbiology annual conference in Birmingham UK entitled 'Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation'.
Gerry travelled to Ventura, California to present a poster and a talk at the Gordon Research Conference 'Translation Machinery in Health & Disease'.
Happy New Year!
Marc's latest paper, 'Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation', has been accepted for publication in PLoS Pathogens.
We have received funding for 4 years (2015-2018) from the Swedish Research Council (Vetenskapsrådet) for our work on 'Regulation Of Cellular Stress Responses In Virus Infection'.
Marc Panas successfully defended his PhD thesis "Dissection of virus-host cell interactions in the early response to infection".
Lifeng Liu joined the group as a PhD student.
Gerry travelled to Halifax, Novia Scotia to present at the 1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral Infection. A report from the conference has been published here.
Lifeng Liu has received a scholarship from the China Scholarship Council (CSC) to pursue his PhD studies in the group. He will join us in September. Very Welcome!
We have received a Karolinska Institutet Doktorand (KID) grant to recruit a new PhD student in the coming year. This position will be advertised in the Autumn Term.
Marc's latest paper, 'The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BP', has been accepted for publication in the Journal of Virology.
Dr. Bastian Thaa has received a 2-year postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (DFG) and will join the group in 2014. Very Welcome!
Gerry and two students from the Summer Research School were interviewed on Sveriges Radio Metropol. Listen here (Swedish).
The group was joined by Stina Sellberg (KI medical student) and Julia Kolb (Leonardo Da Vinci Program student from DKFZ Heidelberg) for summer internships.
A profile of Gerry's research and teaching activities was published in this month's issue of Autophagy.
Gerry gave a talk, 'Sequestration of G3BP by Semliki Forest virus nsP3 inhibits the assembly of stress granules on viral mRNAs', at the Keystone Positive Strand RNA Viruses meeting in Boston, USA.
Marc received two travel grants to present his work at the 23rd Annual Meeting of the German Society for Virology in Kiel, Germany (March 2013) and the 5th European Congress of Virology in Lyon France (September 2013).
Gerry was promoted to Associate Professor of Virology (Docent i Virologi) by Karolinska Institutets Docenturnämnden.