Publications

Selected publications, 2005 - present


Full publication list can be found here.


2022

Leo Hanke*, Daniel J. Sheward*, Alec Pankow, Laura Perez Vidakovics, Vivien Karl, Changil Kim, Egon Urgard, Natalie L. Smith,

Juan Astorga-Wells, Simon Ekström, Jonathan Coquet, Gerald M. McInerney# and Ben Murrell# (2022) Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralising SARS-CoV-2 nanobodies. Science Advances, Accepted for publication. *,# equal contribution
bioRxiv version here.


Leo Hanke*, Hrishikesh Das*, Daniel J. Sheward, Laura Vidakovics Perez, Egon Urgard, Ainhoa Moliner-Morro, Vivien Karl, Alec Pankow, Changil Kim, Natalie L Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K Pedersen, Jonathan Coquet, B. Martin Hällberg, Ben Murrell# and Gerald M. McInerney# (2022) A bispecific monomeric nanobody induces spike trimer dimers and suppresses SARS-CoV-2 in vivo. Nature Communications, 13: 155. *,# equal contribution.


2021

Thomas Kruse, Caroline Benz, Dimitriya H. Garvanska, Richard Lindqvist, Filip Mihalic, Fabian Coscia, Ravi Teja, Inturi, Ahmed Sayadi, Leandro Simonetti, Emma Nilsson, Muhammad Ali, Johanna Kliche, Ainhoa Moliner Morro, Andreas Mund, Eva Andersson, Gerald McInerney, Matthias Mann, Per Jemth, Norman E Davey, Anna K Överby, Jakob Nilsson, Ylva Ivarsson (2021) Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities. Nature Communications,12(1):6761.

Daniel J Sheward, Marco Mandolesi, Changil Kim, Leo Hanke, Laura Perez Vidakovics, Gerald McInerney, Gunilla Karlsson Hedestam, Ben Murrell (2021) Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models. Cell Reports Medicine, 16;2(11):100450.


Atefeh Khorsand Kheirabad, Xuefeng Pan, Siwen Long, Zdravko Kochovski, Yan Lu, Gerald McInerney, Jiayin Yuan (2021) Colloidal dispersion of poly(ionic liquid)/Cu composite particles for protective surface coating against SARS-CoV-2. Nano Select doi.org/10.1002/nano.202100069.


Hendrik Reuper, Benjamin Götte, Lucy Williams, Timothy J.C. Tan, Gerald McInerney, Marc D. Panas and Björn Krenz (2021) Arabidopsis thaliana G3BP ortholog rescues mammalian stress granule phenotype across kingdoms. International Journal of Molecular Sciences 22(12):6287.


Niclas Roxhed, Annika Bendes, Matilda Dale, Cecilia Mattsson, Leo Hanke, Tea Dodig-Crnkovic, Birthe Meineke, Simon Elsässer, Juni Andréll, Sebastian Havervall, Charlotte Thålin, Carina Eklund, Joakim Dillner, Mun-Gwan Hong, Cecilia E Thomas, Olof Beck, Gerald McInerney, Benjamin Murrell, Claudia Fredolini and Jochen M Schwenk (2021) A translational and multiplexed serology approach to determine the prevalence of anti-SARS-CoV-2 antibodies in home-sampled blood. Nature Communications, 12(1):3695.


Padryk Merkl*, Siwen Long*, Gerald M. McInerney#, and Georgios A. Sotiriou# (2021) Antiviral activity of silver, copper oxide and zinc oxide nanoparticle coatings against SARS-CoV-2. Nanomaterials, 17;11(5):1312
*,# equal contribution


Xaquin Castro Dopico, Sandra Muschiol, Murray Christian, Leo Hanke, Daniel J. Sheward, Nastasiya F. Grinberg, Joanna Rorbach, Gordana Bogdanovic, Gerald M. McInerney, Tobias Allander, Chris Wallace, Ben Murrell, Jan Albert, Gunilla B. Karlsson Hedestam (2021) Sero-positivity in blood donors and pregnant women during the first 12 months of SARS-CoV-2 transmission in Stockholm, Sweden. J Internal Medicine, doi:10.1111/joim.13304.


Marco Mandolesi, Daniel J Sheward, Leo Hanke, Junjie Ma, Pradeepa Pushparaj, Laura Perez Vidakovics, Kim Chang Il, Karin Loré, Xaquin Castro Dopico, Jonathan Coquet, Gerald McInerney, Gunilla Karlsson Hedestam, Ben Murrell (2021) SARS-CoV-2 protein subunit vaccines reproducibly elicit potent neutralizing antibody responses. Cell Reports Medicine 2:100252.


Inga Szurgot, Leo Hanke, Daniel J. Sheward, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney and Peter Liljeström (2021) DNA-launched RNA Replicon Vaccines Induce Potent anti-SARS-CoV-2 Immune Responses in mice. Scientific Reports 11:3125.


K. Wørzner, D. Sheward, S. Tandrup Schmidt, L. Hanke, J. Zimmermann, G. McInerney, G. B. Karlsson Hedestam, B. Murrell, D. Christensen and G. K. Pedersen (2021) Adjuvanted SARS-CoV-2 spike protein facilitates neutralizing antibodies and CD4 T cell responses after a single immunization in mice. EBioMedicine 63:103197


2020

Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward, Hrishikesh Das, Tim Schulte, Ainhoa Moliner-Morro, Martin Corcoran, Adnane Achour, Gunilla B. Karlsson Hedestam, B. Martin Hällberg, Ben Murrell and Gerald M. McInerney (2020) An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Nature Communications, 11(1):4420


Götte B, Utt A, Fragkoudis R, Merits A and McInerney G (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. J Virol, 94:e01681-19.


van Huizen, E. and McInerney G.M. (2020) Activation of the PI3K-Akt pathway by Old World alphaviruses. Cells, 9(4):970.



2019

Liu L, Weiss E, Panas MD, Götte B, Sellberg S, Thaa B and McInerney GM (2019). RNA Processing Bodies are Disassembled during Old World Alphavirus Infection. J Gen Virol, 100:1375-138.


Benjamin Götte, Marc D Panas, Kirsi Hellstrom, Lifeng Liu, Baila Samreen, Ola Larsson, Tero Ahola, Gerald M McInerney (2019) 

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery. PLoS Pathogens, 15(6):e1007842.



2018

Götte, B, Liu, L and McInerney GM. (2018) The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last. Viruses 10(3): 105


Mazzon M, Castro C, Thaa B, Liu L, Mutso M, Liu X, Mahalingam S, Griffin JL, Marsh M and McInerney GM. (2018) Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.  PLoS Pathogens,14(1):e1006835.



2016

Schulte T, Liu L, Panas MD, Thaa, B, Dickson N, Götte B, Achour A and McInerney GM. (2016) Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Open Biology, doi: 10.1098/rsob.160078.


Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. (2016) G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 212:845-60.



2015

Thaa, B., Biasiotto, R., Eng, K., Neuvonen, M., Götte, B., Rheinemann, L., Balistreri, G., Merits, A., Ahola, T. and McInerney, G.M. (2015) Differential PI3K–Akt–mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. J Virol, 89:11420-37.


McInerney, G.M. (2015) FGDF Motif Regulation of Stress Granule Formation. DNA Cell Biol. 34:557–5604.


Panas, M.D., Kedersha, N. and McInerney, G.M. (2015)  Methods for the characterization of stress granules in virus infected cells. Methods. doi:10.1016/j.ymeth.2015.04.009.


Panas, M.D., Schulte, T., Thaa, B., Sandalova, T., Achour, A., Kedersha, N.L. and McInerney G.M. (2015). Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation. PLoS Pathogens,11(2):e1004659.


Wang T, Zhan X, Bu CH, Lyon S, Pratt D., Hildebrand S., Choi JH., Zhang Z., Zeng M., Wang KW., Turer E., Chen Z., Zhang D., Yue T., Wang Y., Shi H., Wang J., Sun L., SoRelle J., McAlpine W., Hutchins N., Zhan X., Fina M., Gobert R., Quan J., Kreutzer M., Arnett S., Hawkins K., Leach A., Tate C., Daniel C., Reyna C., Prince L., Davis S., Purrington J., Bearden R., Weatherly J., White D., Russell J., Sun Q., Tang M., Li X., Scott L., Moresco EM., McInerney, G.M., Karlsson Hedestam GB., Xie Y, Beutler B. (2015) Real-time resolution of point mutations that cause phenovariance in mice. PNAS, 112: E440–E449.



2014

Balistreri, G., Horvath, P., Schweingruber, C., Zünd, D., McInerney, G.M., Merits, A., Mühlemann, O., Azzalin, C., Helenius, A. (2014). UPF1 and components of nonsense-mediated mRNA decay restrict replication of mammalian RNA viruses. Cell Host and Microbe, 16:403-411.


Panas, M.D., Ahola, T. and McInerney, G.M. (2014). The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BP. J Virol, 88:5888-5893.



2013

Kuri, T., Smed-Sörensen, A., Thomas, S., Karlsson Hedestam, G.B., Henriques Normark, B., McInerney, G.M. and Plant, L. (2013) Influenza virus enhances IL-12p70 secretion by human dendritic cells infected with Streptococcus pneumoniae. Cellular Micro, 15:1385-400.



2012

Panas, M.D., Varjak, M., Lulla, A., Eng, K.E., Merits, M., Karlsson Hedestam, G.B.  and McInerney, G.M. (2012). Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Mol Biol Cell, 23:4701-4712.


Arnold, C.N., Pirie, E., Dosenovic, P., McInerney, G.M., Siggs, O.M., Xia, Y., Karlsson Hedestam, G.B., and Beutler, B. (2012) A forward genetic screen reveals novel roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immune responses. PNAS, 109:12286-12293.


Klionsky, D. et al., approx 1200 authors listed alphabetically, including Eng, K, and McInerney, G.M.(2012). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 8:445-544.


Pott, J, Stockinger, S., Torow N, Smoczek, A., Lindner, C., McInerney, G.M., Bäckhed, F., Baumann, U., Pabst, O., Bleich, A. and Hornef, M.W. (2012) Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathogens, 8(5):e1002670.


Eng, K.E., Panas, M.D., Murphy, D., Karlsson Hedestam, G.B. and McInerney, G.M. (2012). Accumulation of autophagosomes in Semliki Forest virus infected cells is dependent on the expression of viral structural proteins. J Virol 86:5674-5685.



2011

Adams, W.C., Gujer, C., McInerney, G.M., Gall, J., Petrovas, C., Karlsson Hedestam, G.B., Koup, R.A. and Loré, K. (2011) Adenovirus Type-35 Vectors Block Human CD4+ T Cell Activation by CD46 Ligation. PNAS 108:7499-504.



2010

Eng, K.E., Panas, M., Karlsson Hedestam, G.B., and McInerney, G.M. (2010). A novel flow cytometry based assay for autophagic flux. Autophagy 6:634-641.


Sandgren K.J., Wilkinson, J., Miranda-Saksena, M., McInerney, G.M., Byth-Wilson, K., Robinson, P.J. and Cunningham, A.L. (2010) A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathogens 6(4): e1000866


Siggs, O.M., Berger, M., Krebs, P., Arnold, C.N., Eidenschenk, C., Huber, C., Pirie, E., Smart, N.G., Khovananth, K., Xia, Y., McInerney, G.M., Karlsson Hedestam, G.B., Nemazee, D. and Beutler, B. (2010) A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. PNAS 107: 3046-51



2009

McInerney, G.M. and Karlsson Hedestam, G.B. (2009). Direct cleavage, Proteasomal Degradation and Sequestration: Three mechanisms of viral subversion of type I interferon responses. Review. J Innate Immun 1:599-606.



2007

Breakwell, L., Dosenovic, P., Karlsson Hedestam, G.B., D'Amato, M., Liljeström, P., Fazakerley, J. and McInerney, G.M.(2007). Semliki Forest virus non-structural protein 2 is involved in the suppression of the type I Interferon response. J Virol 81:8677-8684.


Douagi, I., McInerney, G.M., Hidmark, Å.S., Mirallis, V., Johanssen, K., Svensson, L. and Karlsson Hedestam, G. (2007). Role of IRF-3 in Type I IFN Responses in Rotavirus Infected Dendritic cells and Fibroblasts. J Virol 81:2758-2768.



2005

McInerney, G.M., Kedersha, N.L., Kaufman, R.J., Anderson, P. and Liljeström P. (2005). Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell 16:3753–3763.


Hidmark, Å.S., McInerney, G.M., Nordström, E., Douagi, I., Werner, K., Liljeström, P. and Karlsson Hedestam, G.B. (2005). Early a/b interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88. J Virol 79:10376–10385.