The McInerney Laboratory at Karolinska Institutet, Stockholm, Sweden

Selected publications, 2005 - present

Full publication list can be found here.


Benjamin Gotte, Marc D Panas, Kirsi Hellstrom, Lifeng Liu, Baila Samreen, Ola Larsson, Tero Ahola, Gerald M McInerney (2019) 

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery. PLoS Pathogens, accepted for publication.

Currently available on biorXiv.


Götte, B, Liu, L and McInerney GM. (2018)       The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last. Viruses 10(3): 105

Mazzon M, Castro C, Thaa B, Liu L, Mutso M, Liu X, Mahalingam S, Griffin JL, Marsh M and McInerney GM. (2018) Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.  PLoS Pathogens,14(1):e1006835.


Schulte T, Liu L, Panas MD, Thaa, B, Dickson N, Götte B, Achour A and McInerney GM. (2016) Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Open Biology, doi: 10.1098/rsob.160078.

Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. (2016) G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 212:845-60.


Thaa, B., Biasiotto, R., Eng, K., Neuvonen, M., Götte, B., Rheinemann, L., Balistreri, G., Merits, A., Ahola, T. and McInerney, G.M. (2015) Differential PI3K–Akt–mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. J Virol, 89:11420-37.

McInerney, G.M. (2015)    FGDF Motif Regulation of Stress Granule Formation. DNA Cell Biol. 34:557–5604.

Panas, M.D., Kedersha, N. and McInerney, G.M. (2015)  Methods for the characterization of stress granules in virus infected cells. Methods.         doi:10.1016/j.ymeth.2015.04.009.

Panas, M.D., Schulte, T., Thaa, B., Sandalova, T., Achour, A., Kedersha, N.L. and McInerney G.M. (2015). Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation. PLoS Pathogens,11(2):e1004659.

Wang T, Zhan X, Bu CH, Lyon S, Pratt D., Hildebrand S., Choi JH., Zhang Z., Zeng M., Wang KW., Turer E., Chen Z., Zhang D., Yue T., Wang Y., Shi H., Wang J., Sun L., SoRelle J., McAlpine W., Hutchins N., Zhan X., Fina M., Gobert R., Quan J., Kreutzer M., Arnett S., Hawkins K., Leach A., Tate C., Daniel C., Reyna C., Prince L., Davis S., Purrington J., Bearden R., Weatherly J., White D., Russell J., Sun Q., Tang M., Li X., Scott L., Moresco EM., McInerney, G.M., Karlsson Hedestam GB., Xie Y, Beutler B. (2015) Real-time resolution of point mutations that cause phenovariance in mice. PNAS, 112: E440–E449.


Balistreri, G., Horvath, P., Schweingruber, C., Zünd, D., McInerney, G.M., Merits, A., Mühlemann, O., Azzalin, C., Helenius, A. (2014). UPF1 and components of nonsense-mediated mRNA decay restrict replication of mammalian RNA viruses. Cell Host and Microbe, 16:403-411.

Panas, M.D., Ahola, T. and McInerney, G.M. (2014). The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BP. J Virol, 88:5888-5893.


Kuri, T., Smed-Sörensen, A., Thomas, S., Karlsson Hedestam, G.B., Henriques Normark, B., McInerney, G.M. and Plant, L. (2013) Influenza virus enhances IL-12p70 secretion by human dendritic cells infected with Streptococcus pneumoniae. Cellular Micro, 15:1385-400.


Panas, M.D., Varjak, M., Lulla, A., Eng, K.E., Merits, M., Karlsson Hedestam, G.B.  and McInerney, G.M. (2012). Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Mol Biol Cell, 23:4701-4712.

Arnold, C.N., Pirie, E., Dosenovic, P., McInerney, G.M., Siggs, O.M., Xia, Y., Karlsson Hedestam, G.B., and Beutler, B. (2012) A forward genetic screen reveals novel roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immune responses. PNAS, 109:12286-12293.

Klionsky, D. et al., approx 1200 authors listed alphabetically, including Eng, K, and McInerney, G.M.(2012). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 8:445-544.

Pott, J, Stockinger, S., Torow N, Smoczek, A., Lindner, C., McInerney, G.M., Bäckhed, F., Baumann, U., Pabst, O., Bleich, A. and Hornef, M.W. (2012) Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathogens, 8(5):e1002670.

Eng, K.E., Panas, M.D., Murphy, D., Karlsson Hedestam, G.B. and McInerney, G.M. (2012). Accumulation of autophagosomes in Semliki Forest virus infected cells is dependent on the expression of viral structural proteins. J Virol 86:5674-5685.


Adams, W.C., Gujer, C., McInerney, G.M., Gall, J., Petrovas, C., Karlsson Hedestam, G.B., Koup, R.A. and Loré, K. (2011) Adenovirus Type-35 Vectors Block Human CD4+ T Cell Activation by CD46 Ligation. PNAS 108:7499-504.


Eng, K.E., Panas, M., Karlsson Hedestam, G.B., and McInerney, G.M. (2010). A novel flow cytometry based assay for autophagic flux. Autophagy 6:634-641.

Sandgren K.J., Wilkinson, J., Miranda-Saksena, M., McInerney, G.M., Byth-Wilson, K., Robinson, P.J. and Cunningham, A.L. (2010) A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathogens 6(4): e1000866

Siggs, O.M., Berger, M., Krebs, P., Arnold, C.N., Eidenschenk, C., Huber, C., Pirie, E., Smart, N.G., Khovananth, K., Xia, Y., McInerney, G.M., Karlsson Hedestam, G.B., Nemazee, D. and Beutler, B. (2010) A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. PNAS 107: 3046-51


McInerney, G.M. and Karlsson Hedestam, G.B. (2009). Direct cleavage, Proteasomal Degradation and Sequestration: Three mechanisms of viral subversion of type I interferon responses. Review. J Innate Immun 1:599-606.


Breakwell, L., Dosenovic, P., Karlsson Hedestam, G.B., D'Amato, M., Liljeström, P., Fazakerley, J. and McInerney, G.M.(2007). Semliki Forest virus non-structural protein 2 is involved in the suppression of the type I Interferon response. J Virol 81:8677-8684.

Douagi, I., McInerney, G.M., Hidmark, Å.S., Mirallis, V., Johanssen, K., Svensson, L. and Karlsson Hedestam, G. (2007). Role of IRF-3 in Type I IFN Responses in Rotavirus Infected Dendritic cells and Fibroblasts. J Virol 81:2758-2768.


McInerney, G.M., Kedersha, N.L., Kaufman, R.J., Anderson, P. and Liljeström P. (2005). Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell 16:3753–3763.

Hidmark, Å.S., McInerney, G.M., Nordström, E., Douagi, I., Werner, K., Liljeström, P. and Karlsson Hedestam, G.B. (2005). Early a/b interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88. J Virol 79:10376–10385.